South Carolina cities starting with S
- Saint George, SC 11
- Saint Matthews, SC 10
- Saint Stephen, SC 8
- Salem, SC 10
- Salley, SC 12
- Salters, SC 7
- Saluda, SC 30
- Santee, SC 12
- Scranton, SC 11
- Seneca, SC 56
- Sharon, SC 12
- Simpsonville, SC 60
- Six Mile, SC 11
- Smoaks, SC 10
- Smyrna, SC 7
- Society Hill, SC 5
- Spartanburg, SC 173
- Springfield, SC 8
- Starr, SC 9
- St. George, SC 10
- St. Matthews, SC 14
- St. Stephen, SC 11
- Summerton, SC 16
- Summerville, SC 100
- Sumter, SC 141
- Surfside Beach, SC 14
- Swansea, SC 16