North Carolina cities starting with S
- Saint Pauls, NC 12
- Salemburg, NC 8
- Salisbury, NC 118
- Saluda, NC 7
- Sandy Ridge, NC 5
- Sanford, NC 122
- Scotland Neck, NC 11
- Scranton, NC 6
- Seaboard, NC 5
- Seagrove, NC 18
- Selma, NC 33
- Semora, NC 5
- Seven Springs, NC 6
- Shallotte, NC 17
- Shannon, NC 10
- Shelby, NC 96
- Sherrills Ford, NC 7
- Siler City, NC 46
- Sims, NC 5
- Smithfield, NC 53
- Sneads Ferry, NC 6
- Snow Camp, NC 18
- Snow Hill, NC 15
- Sophia, NC 11
- Southern Pines, NC 23
- South Mills, NC 10
- Southport, NC 21
- Sparta, NC 14
- Spencer, NC 8
- Spindale, NC 13
- Spring Hope, NC 19
- Spring Lake, NC 33
- Spruce Pine, NC 32
- Staley, NC 9
- Stanfield, NC 9
- Stanley, NC 20
- Stantonsburg, NC 5
- Star, NC 6
- State Road, NC 11
- Statesville, NC 153
- Stedman, NC 8
- Stokesdale, NC 9
- Stoneville, NC 14
- Stony Point, NC 12
- St. Pauls, NC 9
- Summerfield, NC 11
- Sunbury, NC 6
- Supply, NC 15
- Swannanoa, NC 22
- Swanquarter, NC 6
- Swansboro, NC 6
- Sylva, NC 34