Missouri cities starting with S
- Saint Ann, MO 9
- Saint Charles, MO 42
- Saint Clair, MO 12
- Sainte Genevieve, MO 10
- Saint James, MO 11
- Saint Joseph, MO 57
- Saint Louis, MO 349
- Saint Peters, MO 21
- Saint Robert, MO 7
- Salem, MO 36
- Salisbury, MO 13
- Sarcoxie, MO 14
- Savannah, MO 10
- Scott City, MO 13
- Sedalia, MO 61
- Sedgewickville, MO 6
- Senath, MO 6
- Seneca, MO 14
- Seymour, MO 16
- Shelbina, MO 8
- Shelbyville, MO 6
- Shell Knob, MO 11
- Sikeston, MO 43
- Silex, MO 7
- Slater, MO 11
- Smithville, MO 16
- Sparta, MO 5
- Springfield, MO 275
- Stanberry, MO 5
- St. Charles, MO 37
- St. Clair, MO 8
- Steele, MO 13
- Steelville, MO 12
- Stella, MO 6
- Stewartsville, MO 7
- St. Joseph, MO 42
- St Louis, MO 14
- St. Louis, MO 342
- Stockton, MO 13
- Stover, MO 6
- St. Peters, MO 21
- Strafford, MO 8
- St. Robert, MO 6
- Sugar Creek, MO 5
- Sullivan, MO 27
- Summersville, MO 8
- Sunrise Beach, MO 5
- Sweet Springs, MO 9